CD8+ T cells can eradicate abnormal cells through the recognition of small peptides presented by major histocompatibility complex (MHC) class I molecules. In this study, a system-level and cross-species analysis of the MHC-I immunopeptidome was conducted to understand how the MHC-I immunopeptidome is being shaped in different primary tissues in vivo.

Umami is the fifth taste found in substances that mainly include amino acids and nucleotides. Here, the combination of peptidomics and virtual screening is employed for rapid screening of samples to identify novel umami peptides in clam species.