Bioinformatics Solutions Inc. Announces PEAKS GlycanFinder 2.5

Today, Bioinformatics Solutions Inc. (BSI) is excited to announce the release of PEAKS GlycanFinder 2.5, the latest innovation in glycoproteomics and glycomics data analysis. With enhanced glycan profiling capabilities and new quantification workflows, PEAKS GlycanFinder 2.5 empowers researchers to explore glycan heterogeneity with greater accuracy and confidence.

Unlocking the Complexity of Glycosylation

Glycosylation plays a critical role in biological processes, yet its structural complexity presents significant analytical challenges. PEAKS GlycanFinder 2.5 offers cutting-edge solutions for intact glycopeptide identification, glycan profiling, and site-specific glycosylation analysis, providing researchers with a comprehensive and intuitive toolset to streamline data interpretation.

What’s New in PEAKS GlycanFinder 2.5?

• Integrated Glycoproteomics and Glycomics Solutions – Characterize and quantify both intact glycopeptides and released glycans within a unified workflow.
• Expanded Glycan Profiling for N-linked and O-linked Glycans – Enhanced structural confidence in glycan characterization.
• Accurate and Flexible Quantification – Support for label-free and reporter ion-based glycopeptide quantification, including a new PRM quantification workflow.

What’s Enhanced?

• Comprehensive Glycosylation Site Profiling – Utilize multiple enzyme digests for a broader and more detailed panorama of glycosylation sites.
• Glycan de novo Sequencing – Discover novel glycans that may not be present in existing databases.
• Vendor-Neutral Data Compatibility – Analyze data from Orbitrap, timsTOF, and ZenoTOF instruments seamlessly.
• Enhanced Visualization and Reporting – Improved GUI for streamlined validation and data exploration.

Bridging Glycomics and Glycoproteomics

With Released Glycan Sample Profiling, PEAKS GlycanFinder 2.5 enables in-depth characterization of released glycans. The software now supports customized glycan modifications, adduct searches, and cross-ring annotation, providing more detailed glycan spectrum interpretation. Additionally, Released Glycan Reporter Ion Quantification (RIQ) enhances sensitivity and reproducibility, ensuring confident glycan abundance measurements across samples.

Unprecedented Quantification Capabilities

Quantification remains a cornerstone of glycoproteomics, and PEAKS GlycanFinder 2.5 introduces key advancements:

• Label-Free Quantification (LFQ) – Reliable feature alignment across multiple samples for confident abundance measurements.
• Reporter Ion Quantification (RIQ) – Support for user-defined and commercial labels such as iTRAQ and TMT.
• New PRM Quantification Workflow – Targeted glycopeptide quantification with MS2 structural annotation.

Decipher Glycan Associations using Glycan Network

PEAKS GlycanFinder 2.5 introduces an intuitive Glycan Network, illustrating relationships between glycan compositions. By visualizing how glycans differ by a single monosaccharide, researchers can uncover functional and biological glycan associations more effectively.

Resolve Glycan Ambiguity with Structural Resolution (S-Score)

To enhance glycan structure confidence, PEAKS GlycanFinder 2.5 provides an S-Score (%). This ensures higher accuracy in glycopeptide identification.

Experience the Next Generation of Glycoproteomics and Glycomics

With PEAKS GlycanFinder 2.5, researchers can push the boundaries of glycan analysis, gaining deeper insights into glycosylation dynamics with confidence and ease. Request a demo today and elevate your glycomics and glycoproteomics research with PEAKS.

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For more details on PEAKS GlycanFinder 2.5, visit our website and explore the latest advancements in glycan analysis!