Phospholipase A2 from krait Bungarus fasciatus venom induces human cancer cell death in vitro

0
On 2019-12-032019-12-11By In User Publications
Tran TV, Siniavin AE, Hoang AN, Le MTT, Pham CD, Phung TV, Nguyen KC, Ziganshin RH, Tsetlin VI, Weng C, Utkin YN. 2019. Phospholipase A2 from krait Bungarus fasciatus venom induces human cancer cell death in vitro. PeerJ 7:e8055 https://doi.org/10.7717/peerj.8055
Snake venoms are the complex mixtures of different compounds manifesting a wide array of biological activities. The venoms of kraits (genus Bungarus, family Elapidae) induce mainly neurological symptoms; however, these venoms show a cytotoxicity against cancer cells as well. This study was conducted to identify in Bungarus fasciatus venom an active compound(s) exerting cytotoxic effects toward MCF7 human breast cancer cells and A549 human lung cancer cells.